Superflo® columns are based on radial flow chromatography. The columns have three annular channels. The outer and inner channels have equal cross-sectional areas and conduct the fluid flow to the outlet. The middle channel contains the chromatographic packing. The sample is introduced at the sample inlet from which it is distributed evenly throughout the center channel. From this outer channel, the sample flows through a porous tube and into the packing material where the sample constituents are selectively bound. After an elution procedure, the sample components pass sequentially through the inner porous tube of the column and out the column outlet.

Due to the large cross-sectional area of the outer channels and the low bed depth, Superflo® columns allow extremely high flow rates with very little pressure drop.

Superflo® Columns are based on unique radial flow geometry and are ideally suited for high throughput preparative and bioprocess applications.

Technical features of radial flow chromatography:

l  Easy to scale up

l  Higher flow rate、Shorter Process Time、Faster Time to Market

l  The required column is smaller and the resin is less. Better Economics

Case study

Radial flow columns are often used in process development and clinical production in laboratories around the world. More than 20 FDA-approved drugs, including immunoglobulins and clotting factors in human plasma, vaccine interferons, and several recombinant drugs, are purified on Superflo ® columns.